施志浩，副教授，1978年12月出生，博士，2007年毕业于南京理工大学，同年进入中国药科大学理学院有机教研室工作至今。于2015年4月至2016年4月作为访问学者赴加拿大多伦多大学进行为期一年的研究工作, 主要学习金属催化剂在构建杂环分子合成中的应用。现主要研究方向为小分子抗肿瘤药物的设计与合成及基于天然产物结构的活性小分子化合物的结构改造与修饰。
主持和参与的基金项目：
1.基于二芳基脲骨架的新型不可逆酪氨酸激酶抑制剂的设计、合成及构效关系研究（国家自然基金青年项目资助21302225，主持）
2.基于二芳基脲骨架的新型不可逆酪氨酸激酶抑制剂的设计、合成及构效关系研究(中央高校基本科研业务费PT2014LX0072，主持)
3.新型不可逆酪氨酸激酶抑制剂的设计、合成及构效关系研究(中央高校基本科研业务费青年基金JKQ2009013，主持)
4.基于片段的新型BET Bromodomain小分子抑制剂的设计、合成与生物活性研究（国家自然基金面上81473077，参与）
发表文章：
1.Zhi-Hao Shi, Feng-Tao Liu, Hao-Zhong Tian, Yan-Min Zhang, Nian-Guang Li*, Tao Lu*. Design, synthesis and structure-activity relationship of diaryl-ureas with novel isoxazol[3,4-b]pyridine-3-amino-structure as multi-target inhibitors against receptor tyrosine kinase. Bioorganic & Medicinal Chemistry,2018, 26(16), 4735–4744.
2.Wenyu Wu, Shaopeng Yu, Ting Gu, Tianyuan Fan, Yue Zhong, Nian-Guang Li*, Yuping Tang*, Yi Jiang, Xingmei Zhu, Jinao Duan*,Zhihao Shi*. Norbornene Mediated Palladium-Catalyzed Domino-Type Catellani Reaction: An Efficient and Regiospecific Acylation/Suzuki Coupling of Aryl Iodides. European Journal of Organic Chemistry, 2018, 24, 3075–3085.
3.Yue Zhong, Yu-Ting Lu, Ying Sun, Zhi-Hao Shi, Nian-Guang Li*, Yu-Ping Tang* and Jin-Ao Duan. Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer. Expert Opnionon Drug Discovery, 2018, 13(1), 75–87.
4.Juntao Ye, Zhihao Shi, Theresa Sperger, Yoshifumi Yasukawa, Cian Kingston,Franziska Schoenebeck* and Mark Lautens*. Remote C−H alkylation and C−C bond cleavageenabled by an in situ generated palladacycle. Nature Chemistry, 2017, 9(4), 361–368.
5.Khan T. Osman, Juntao Ye, Zhihao Shi, Christina Toker, Diogo Lovato, Rajiv S. Jumani, William Zuercher, Christopher D. Houston, Aled M. Edwards, Mark Lautens*, Vijayaratnam Santhakumar*, Raymond Hui*. Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor. Bioorganic & Medicinal Chemistry,2017, 25(5), 1672-1680.
6.Wen-Yu Wu, Yu-Chen Dai, Nian-Guang Li*, Ze-Xi Dong, Ting Gu, Zhi-Hao Shi, Xin Xue, Yu-Ping Tang*,and Jin-Ao Duan*. Novel multitarget-directed tacrine derivatives as potential candidates for thetreatment of Alzheimer’s disease. Journal of Enzyme Inhibition and Medicinal Chemistry,2017, 32(1), 572-587.
7.Wei Zhang, Nian-Guang Li*, Yu-Ping Tang, Ze-Xi Dong, Ting Gu, Wen-Yu Wu, Peng-Xuan Zhang,Shao-Peng Yu, Jin-Ao Duan and Zhi-Hao Shi*. Investigation of 6-O-methyl-scutellareinmetabolites in rats by ultra-flow liquidchromatography/quadrupole-time-of-flight massspectrometry. Pharmaceutical Biology, 2016, 54(10), 2158-2167.
8.Ze-Xi Dong, Zhi-Hao Shi, Nian-Guang Li*,Wei Zhang, Ting Gu, Peng-Xuan Zhang,Wen-Yu Wu, Yu-Ping Tang*, Fang Fang, XinXue, He-Min Li, Hai-Bo Cheng, Jian-PingYang and Jin-Ao Duan.*Design, Synthesis, and Biological Evaluation ofScutellarein Derivatives Based on Scutellarin MetabolicMechanism In Vivo. Chemical Biology & Drug Design,2016, 87(6), 946–957.
9.Zhang Wei, Dong Ze-Xi, Gu Ting, Li Nian-Guang*, Wu Wen-Yu, Zhang Peng-Xuan, Tang Yu-Ping, Yang Jian-Ping, Xue Xin, Fang Fang, Li He-Min, Cheng Hai-Bo, Duan Jin-Ao, Shi Zhi-Hao. An improved synthesis of 6-O-methyl-scutellarein through selective benzylation. Journal of Chemical Research, 2015, 39(11), 674-676.
10.Zhi-Hao Shi, Nian-Guang Li*, Zhen-Jiang Wang, Yu-Ping Tang*, Ze-Xi Dong,Wei Zhang, Peng-Xuan Zhang, Ting Gu, Wen-Yu Wu, Jian-Ping Yang,Jin-Ao Duan*. Synthesis and biological evaluation of methylated scutellarein analogsbased on metabolic mechanism of scutellarin in vivo. European Journal of Medicinal Chemistry,2015, 106, 95-105.
11.Zhi-Hao Shi, Nian-Guang Li*, Qian-Ping Shi, Wei Zhang, Ze-Xi Dong, Yu-Ping Tang*,Peng-Xuan Zhang, Ting Gu, Wen-Yu Wu, Fang Fang, Xin-Xue, He-Min Li, Jian-Ping Yang,Jin-Ao Duan*. Synthesis of scutellarein derivatives to increase biological activityand water solubility. Bioorganic & Medicinal Chemistry,2015, 23(21), 6875–6884.
12.Hao Tang, Zhi-Hao Shi, Nian-Guang Li*, Yu-Ping Tang*, Qian-Ping Shi, Ze-Xi Dong. Peng-Xuan Zhang, Jin-Ao Duan. Investigation on the interactions of scutellarin and scutellareinwith bovine serum albumin using spectroscopic and moleculardocking techniques. Archives of Pharmacal Research, 2015, 38(10), 1789–1801.
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