钱海研究员，博士生导师，现任理学院院长&药物科学研究院新药研究中心主任。
主要从事创新药物分子发现和结构优化研究。针对糖尿病、肿瘤、疼痛等重大临床问题，以多肽、核酸和小分子药物为研究对象，基于药物靶点及药物分子的结构特点进行合理设计，并从受体、细胞及整体动物等不同层面深入探讨和确证相关化合物的药效机制，为创新药物开发奠定坚实基础。
在创新药物研究方面已取得一系列重要成果。合成得到了超过1500个全新化合物，发现具有良好成药性、值得进一步开发的活性化合物超过20个，4个候选化合物正处于临床前研究阶段；一项静脉麻醉药物已转让国内知名药企。
发表SCI收录学术期刊论文100多篇。申请中国专利29项，国际专利4项，授权中国专利10余项。已指导博士研究生12名，硕士研究生54名。曾获第13届中国药学会施维雅青年药物化学奖，2013年增补为江苏省“333高层次人才培养工程”第三层次培养对象。
近期发表主要论著：
1. Wei Shi, Qianqian Qiu, Ziying Feng, Zhenzhen Tong,Weiwei Guo, Feng Zou, Na Yue, Wenlong Huang, Hai Qian*. Design, synthesis and immunological evaluation of self- assembled antigenic peptides from dual-antigen targets: a broad-spectrum candidate for an effective anti-breast cancer therapy. Journal for ImmunoTherapy of Cancer, 2021 (9) e002523.
2. Jiaqi Zhou, Yuxing Zou, Yan Cai, Fanglian Chi, Wenlong Huang, Wei Shi *, Hai Qian*. A designed cyclic peptide based on Trastuzumab used to construct peptide-drug conjugates for its HER2-targeting ability. Bioorganic Chemistry. 2021(117), 105453.
3. Qianqian Qiu#, Feng Zou#, Huilan Li#, Wei Shi, Daoguang Zhou, Ping Zhang, Teng Li, Ziyu Yin, Zilong Cai, Yuxuan Jiang, Wenlong Huang, and Hai Qian*. Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P‐gp- and BCRP-Mediated Multidrug Resistance. Journal of Medicinal Chemistry, 2021(64), 6179−6197.
4. Yuxuan Dai, Na Yue, Junni Gong , Chunxia Liu , Qifei Li , Jiaqi Zhou , Wenlong Huang , Hai Qian * .Development of cell-permeable peptide-based PROTACs targeting estrogen receptor a. European Journal of Medicinal Chemistry, 2020(187), 111967.
5. Yao Ma#, Dawei Yin#, Jingjia Ye#, Xiduan Wei, Yameng Pei, Xueyuan Li, Guangxu Si, Xuan-Yu Chen, Zhe-Sheng Chen, Yi Dong, Feng Zou, Wei Shi, Qianqian Qiu, Hai Qian*, Gang Liu*. Discovery of Potent Inhibitors against P‐Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2‐(4-(Pyridin-2-yl)phenoxy)pyridine Analogue. Journal of Medicinal Chemistry, 2020(63), 5458−5476.
6. Dai Yuxuan, Cai Xingguang, Bi Xinzhou, Liu Chunxia, Yue Na, Zhu Ying, Zhou Jiaqi, Fu Mian, Huang Wenlong, Qian Hai*. Synthesis and anti-cancer evaluation of folic acid-peptide- paclitaxel conjugates for addressing drug resistance. European Journal of Medical Chemistry, 2019, 171:104-115.
7. Qiu Qianqian#, Liu Baomin#, Cui Jian, Li Zheng, Deng Xin, Qiang Hao, Li Jieming, Liao Chen, Zhang Bo, Shi Wei, Pan Miaobo, Huang Wenlong*, Qian Hai*. Design, Synthesis, and Pharmacological Characterization of N‑(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P‑Glycoprotein-Mediated Multidrug Resistance. Journal of Medicinal Chemistry, 2017, 60(8):3289-3302.
8. Qiu Qianqian, Shi Wei, Li Zheng, Zhang Bo, Pan Miaobo, Cui Jian, Dai Yuxuan, Huang Wenlong*, Qian Hai*. Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance. Journal of Medicinal Chemistry, 2017, 60(7):2930-2943.
9. Han Jing #, Sun Lidan #, Huang Xun #, Li Zheng, Zhang Chenyu, Qian Hai *, Huang Wenlong*. Novel coumarin modified GLP-1 derivatives with enhanced plasma stability and prolonged in vivo glucose-lowering ability. British Journal of Pharmacology, 2014, 171(23):5252-5264.
10. Han Jing#, Sun Lidan#, Chu Yingying, Li Zheng, Huang Dandan, Zhu Xiaoyun, Qian Hai*, Huang Wenlong*. Design, synthesis, and biological activity of novel dicoumarol glucagon-like peptide 1 conjugates. Journal of Medicinal Chemistry, 2013, 56(24):9955-9968.
联系地址：江苏省南京市江宁大学城中国药科大学理学院（211198）
电 话：025-86185180
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E-mail: qianhai24@cpu.edu.cn or qianhai24@163.com