张晓进

来源:赵飞发布时间:2022-09-15浏览次数:6165

 

 

张晓进,男,1986生,药物化学专业副教授,博士生导师。2007年获中国药科大学制药工程专业学士学位,2012年获中国药科大学药物化学专业博士学位,同年留校任教于理学院有机化学教研室2015晋升为副教授现任理学院化学系副主任

近年来以第一作者或通讯作者在Journal of Medicinal ChemistryEuropean Journal of Medicinal ChemistryOrganic Letters等专业领域国际著名刊物上发表SCI收录论文30余篇;申请国际及中国发明专利8项,已授权专利4。现主持国家自然科学基金面上项目,江苏省优秀青年基金项目,主持完成了国家、江苏省自然科学青年基金项目2015年荣获江苏省科学技术奖一等奖(第三完成人),2016年荣获国家科技进步奖二等奖(第四完成人),2016年荣获第十九届中国药学会-施维雅青年药物化学奖,2017入选江苏省青蓝工程优秀青年骨干教师培养对象2018入选江苏省333高层次人才培养工程”第三层次培养对象作为主要负责人之一研发的一个抗肾性贫血1类新药现已申报临床研究

研究生招生方向新药分子设计与合成研究

主要研究方向围绕细胞氧化还原及氧感受系统开展靶向新药研发、前药设计及化学生物学研究

联系方式zxj@cpu.edu.cn

代表性论文:

1.Zhihong Li, Qidong You,* Xiaojin Zhang.*Small-molecule modulators of the hypoxia-inducible factor pathway: Development and therapeutic applications. Journal of Medicinal Chemistry, 2019, doi: 10.1021/acs.jmedchem.8b01596 (IF=6.253).

2.Zhensheng Jiang, Qidong You,* Xiaojin Zhang.* Medicinal chemistry of metal chelating fragments in metalloenzyme active sites: A perspective. European Journal of Medicinal Chemistry,2019, 165, 172197.(IF=4.519)

3.Xingsen Wu, Xiang Li, Zhihong Li, Yancheng Yu, Qidong You,* Xiaojin Zhang.* Discovery of nonquinone substrates for NAD(P)H: quinone oxidoreductase 1 (NQO1) as effective intracellular ROS generators for the treatment of drug-resistant non-small cell lung cancer. Journal of Medicinal Chemistry, 2018, 61(24), 1128011297. (IF=6.253). (supplementary cover article)

4.Yue Wu, Zhensheng Jiang, Zhihong Li, Jing Gu, Qidong You,* Xiaojin Zhang.* Click chemistry–based discovery of [3-hydroxy-5-(1H-1,2,3-triazol-4-yl)picolinoyl]glycines as orally active hypoxia inducing factor prolyl hydroxylase inhibitors with favorable safety profiles for the treatment of anemia. Journal of Medicinal Chemistry, 2018, 61(12), 5332-5349. (IF=6.253)

5.Xian Zhang, Xiang Li,Zhihong Li, Xingsen Wu, Yue Wu, Qidong You,* Xiaojin Zhang.* An NAD(P)H: quinone oxidoreductase 1 responsive and self-immolative prodrug of 5-fluorouracil for safe and effective cancer therapy. Organic Letters, 2018, 20 (12), 36353638. (IF=6.429)

6.JinleiBian, Xiang Li, Nan Wang, Xingsen Wu, Qidong You,* Xiaojin Zhang.*Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile. European Journal of Medicinal Chemistry,2017, 129, 27-40. (IF=4.519)

7.Xian Zhang, Xiang Li, Qidong You,*Xiaojin Zhang.* Prodrug strategy for cancer cell-specific targeting: a recent overview. European Journal of Medicinal Chemistry, 2017, 139, 542563.(IF=4.519)

8.Jinlei Bian,Xiang Li,Lili XuNan Wang, Xue Qian, Qidong You,*Xiaojin Zhang.*Affinity-based smallfluorescent probe for NAD(P)H:quinone oxidoreductase 1 (NQO1). Design, synthesis and pharmacological evaluation. European Journal of Medicinal Chemistry, 2017, 127, 828-839.(IF=4.519)

9.Jinlei Bian, Xue Qian, Nan Wang, Tong Mu, Xiang Li, Haopeng Sun, Lianshan Zhang, Qidong You,* Xiaojin Zhang.*Palladium(II)-catalyzed CH bond activation/CC coupling/intramolecular Tsuj-Trost reaction cascade: facile access to 2H-pyranonaphthoquinones. Organic Letters, 2015, 17 (14), 34103413. (IF=6.364)

10.Xiaojin Zhang,Xiang Li, Haopeng Sun,* Xiaojian Wang, Li Zhao, Yuan Gao, Xiaorong Liu, Shenglie Zhang, Yanyan Wang, Yingrui Yang, Su Zeng, Qinglong Guo,* Qidong You.* Garciniaxanthones as orally active antitumor agents. Journal of Medicinal Chemistry, 2013,56(1), 276−292.(IF=5.614)